Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parE	I139R	T418G	-	-	fluoroquinolones	Reslit	Candidate
parE DNA topoisomerase IV subunit A	I148V	-	-	Streptococcus agalactiae	ciprofloxacin	Reslit	Candidate
parE topoisomerase IV subunit B	I255T	-	-	Escherichia coli	fluoroquinolones	Reslit	Candidate
parE DNA topoisomerase IV subunit B	I355T	-	Target modification, DNA topoisomerase IV subunit B ParE	Escherichia coli, Klebsiella pneumoniae, E. coli	ciprofloxacinciprofloxacin\|nalidixic acidnalidixic acid\|ciprofloxacin+2 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parE DNA topoisomerase IV subunit B	I444F	ATA -> TTC	Target modification, DNA topoisomerase IV subunit B ParE	Escherichia coli	norfloxacin\|ciprofloxacinnalidixic acid\|ciprofloxacinquinolones	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parE topoisomerase IV subunit E	I444S	-	-	Salmonella Typhi, Salmonella Paratyphi	ciprofloxacin	Reslit	Candidate
parE topoisomerase IV subunit E	I460N	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	Candidate
parE DNA topoisomerase IV parE subunit	I460V	A1380G A1379T	-	Streptococcus pneumoniae	ciprofloxacin\|garenoxacin\|sparfloxacin\|trovafloxacinfluoroquinolonesmoxifloxacin\|levofloxacin\|gemifloxacin+8 more	Reslit	Supported
parE DNA topoisomerase IV subunit B	I464F	-	Target modification, DNA topoisomerase IV subunit B ParE	Escherichia coli	ciprofloxacin\|nalidixic acidciprofloxacin\|enrofloxacinfluoroquinolones+2 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parE	I470M	-	Target modification, DNA topoisomerase IV subunit B ParE	Escherichia coli	nalidixic acid\|ciprofloxacinquinolones	Reference Gene CatalogResFinder Database	Confirmed