Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA	ins346D	-	-	Neisseria gonorrhoeae	cephalosporins	ResFinder Database	Established
penA Penicillin-Binding Protein 2	V316P	-	reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxone\|cefiximecefiximeceftazidime\|ceftriaxone+3 more	Reference Gene CatalogReslit	Confirmed
penA penicillin-binding protein 2	V316T	-	decreased susceptibility, reduced reactivity for β-lactams, decreased susceptibility to cefixime and ceftriaxone, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxone\|cefiximecefiximecephalosporins+5 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
penP β-lactamase	E166C	-	impair catalytic activity	Bacillus licheniformis	penicillin\|cephalosporins	Reslit	Candidate
penP β-lactamase	N170Q	-	impair catalytic activity	Bacillus licheniformis	penicillin\|cephalosporins	Reslit	Candidate
penR	V151E	-	beta-lactamase transcriptional regulator PenR	Burkholderia orbicola	carbapenems	Reference Gene Catalog	Established
pepA	T157P	-	-	Pseudomonas aeruginosa	cefuroxime	Reslit	Candidate
pepA protease	Y264C	-	-	Pseudomonas aeruginosa	aztreonam	Reslit	Candidate
pepQ proline aminopeptidase	-	A202G	-	-	bedaquiline	Reslit	Candidate
pepQ proline aminopeptidase	-	C286T	-	-	bedaquiline	Reslit	Candidate