Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaL2 beta-lactamase	I72F	-	enhanced resistance	Escherichia coli, Stenotrophomonas maltophilia	ceftazidime\|cephalexin\|aztreonamcephalexin\|cefazolin\|cefoxitin\|ceftazidime\|ceftriaxone\|cefepime\|aztreonam\|meropenem\|imipenem	Reslit	Candidate
blaLRA-5 β-lactamase	V166E	-	-	E. coli	cephalosporins\|penicillinampicillin\|cephalothin\|ceftazidime\|cefepime\|aztreonam	Reslit	Candidate
blaLRA-5 β-lactamase	Y69Q	-	-	E. coli	cephalosporins\|penicillinampicillin\|cephalothin\|ceftazidime\|cefepime\|aztreonam	Reslit	Candidate
blaNDM-1 metallobeta-lactamase	-	TGC->GCA	reduced catalytic efficiency and stability	Escherichia coli, Enterobacter cloacae	ampicillin\|cefotaxime\|ceftazidime\|cefoxitin\|imipenem\|meropenem	Reslit	Candidate
blaNDM-1 metallo-beta-lactamase	D124A	-	-	E. coli, Klebsiella pneumoniae	carbapenems	Reslit	Candidate
blaNDM-1 Metallo-beta-lactamase	H121R	-	-	Klebsiella spp	carbapenems	Reslit	Candidate
blaNDM-1 metallo-beta-lactamase	N220A	-	-	E. coli, Klebsiella pneumoniae	carbapenems	Reslit	Candidate
blaNDM-1 metallo-beta-lactamase	Q123A	-	-	E. coli, Klebsiella pneumoniae	carbapenems	Reslit	Candidate
blaNDM-4 beta-lactamase	P60A	-	-	E. coli	carbapenems	Reslit	Candidate
blaNDM-5 beta-lactamase	-	G5561A	reduces blaNDM-5 expression, leading to decreased carbapenem resistance	Escherichia coli	carbapenems	Reslit	Candidate