Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
bioC O-methyltransferase	Q116A	-	The Q116A mutation disrupts the neutralization of the malonyl group, affecting substrate binding and enzymatic activity.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bioC O-methyltransferase	Q26A	-	The Q26A mutation disrupts the neutralization of the malonyl group, affecting substrate binding and enzymatic activity.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bioC O-methyltransferase	R212A	-	The R212A mutation affects the interaction with the ACP carrier, reducing enzymatic activity.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bioC O-methyltransferase	W117A	-	The W117A mutation disrupts SAM binding and reduces enzymatic activity, indicating a critical role in BioC function.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bla CMY-16 beta-lactamase	N346H	-	reduced inhibition efficacy of avibactam	Klebsiella pneumoniae	aztreonam\|avibactam	Reslit	Candidate
bla CMY-16 beta-lactamase	Y150S	-	reduced inhibition efficacy of avibactam	Klebsiella pneumoniae	aztreonam\|avibactam	Reslit	Candidate
bla KPC Beta-lactamase	D179Y	-	-	Klebsiella pneumoniae	carbapenems	Reslit	Candidate
bla OXY beta-lactamase	-	G1T	-	-	ceftriaxone	Reslit	Candidate
bla OXY beta-lactamase	-	G5A	-	-	ceftriaxone	Reslit	Candidate
bla TEM-1 beta-lactamase	-	C32T	increases expression	Escherichia coli	amoxicillin clavulanic acid	Reslit	Candidate