Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parE DNA topoisomerase IV subunit	P424Q	-	confers resistance	Streptococcus mitis, Streptococcus pneumoniae	ciprofloxacin	Reslit	Candidate
parE topoisomerase IV subunit E	P439S	-	Target modification, DNA topoisomerase IV subunit B ParE	Haemophilus haemolyticus, Escherichia coli, Haemophilus influenzae, Vibrio sp.	levofloxacin\|tosufloxacin\|moxifloxacinnalidixic acid\|ciprofloxacinquinolones	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parE DNA topoisomaze IV subunit A	P446S	-	-	Ureaplasma parvum, Ureaplasma urealyticum	ofloxacin\|ciprofloxacin\|levofloxacin	Reslit	Candidate
parE topoisomerase IV subunit	P451S	-	DNA topoisomerase IV subunit B ParE	Staphylococcus aureus	fluoroquinolonesquinolones	Reference Gene CatalogReslit	Confirmed
parE DNA topoisomerase IV subunit	P454A	-	-	Streptococcus pneumoniae	clinafloxacin\|ciprofloxacin\|trovafloxacin	Reslit	Candidate
parE DNA topoisomerase IV subunit	P454H	-	-	Streptococcus pneumoniae	clinafloxacin\|ciprofloxacin\|trovafloxacin	Reslit	Candidate
parE DNA topoisomerase IV subunit	P454S	-	-	Streptococcus pneumoniae	clinafloxacin\|ciprofloxacin\|trovafloxacinfluoroquinolones	Reslit	Supported
parE topoisomerase IV subunit B	P456S	-	-	Neisseria gonorrhoeae	ciprofloxacin\|garenoxacin\|sitafloxacin	Reslit	Candidate
parE	P585S	-	DNA topoisomerase IV subunit B ParE	Staphylococcus aureus	quinolones	Reference Gene Catalog	Established
parE	P587S	-	single resistance variant	Staphylococcus aureus	fluoroquinolones	Card Database	Established