Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
piuC PiuC iron-dependent oxygenase (a TonB-dependent transporter) | S116F | - | entailing a switch from an amino acid with polar uncharged side chain (serine) to one with a hydrophobic side chain (phenylalanine), which could be involved in the binding of the siderophore | Pseudomonas aeruginosa | cefiderocol | Reslit | Candidate |
| G354V | - | TonB-dependent siderophore receptor PiuD | Pseudomonas aeruginosa | cefiderocol | Reference Gene Catalog | Established | |
| Q604Ter | - | TonB-dependent siderophore receptor PiuD | Pseudomonas aeruginosa | cefiderocol | Reference Gene Catalog | Established | |
pks8 polyketide synthase | L169V | - | - | Mycobacterium tuberculosis | bedaquiline | Reslit | Candidate |
plcC phospholipase C | Q462R | - | unknown | Mycobacterium tuberculosis | capreomycin | Reslit | Candidate |
pldA phospholipase | T200T | - | outer membrane disorganization | Acinetobacter baumannii | colistin | Reslit | Candidate |
plsX phosphate acyl-ACP acyltransferase | H57Y | - | - | Streptococcus pneumoniae | trimethoprim | Reslit | Candidate |
pmpM efflux pump regulator | - | - | Pseudomonas aeruginosa | fluoroquinolones | Reslit | Candidate | |
pmpM efflux pump regulator | - | - | Pseudomonas aeruginosa | fluoroquinolones | Reslit | Candidate | |
| - | - | - | ciprofloxacin | Reslit | Candidate |
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