Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
blaCTX-M-4 class A beta-lactamase | S237A | - | reduced slightly the relative hydrolytic activity against cefotaxime and the susceptibility to inhibition by clavulanate | Escherichia coli, Salmonella typhimurium | cefotaxime|cefoxitin | Reslit | Candidate |
blaCTXM-1 Extended-spectrum beta-lactamase | S164F | - | - | - | cephalosporins | Reslit | Candidate |
blaCTXM-15 Extended-spectrum beta-lactamase | S164F | - | - | - | cephalosporins | Reslit | Candidate |
blaGES-1 beta-lactamase | A237T | - | impaired catalytic activity | Mycobacterium tuberculosis | carbapenems | Reslit | Candidate |
blaGES-1 β-lactamase | G170S | - | - | Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Acinetobacter baumannii | carbapenems | Reslit | Candidate |
blaGES β-lactamase | G165S | - | Pseudomonas aeruginosa | carbapenems | Reslit | Candidate | |
| H121R | - | - | - | carbapenems | Reslit | Candidate | |
blaIMP metallo-beta-lactamase | S262G | - | increased resistance to meropenem | E. coli, Stenotrophomonas spp., Pseudomonas putida, P. aeruginosa | carbapenems | Reslit | Candidate |
blaIMP metallo-beta-lactamase | V67F | - | - | E. coli | carbapenems | Reslit | Candidate |
blaKPC-2 β-lactamase | D179A | - | - | Escherichia coli | ceftazidime avibactam | Reslit | Candidate |
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